Skip to content

3세부

문 연 실 교수| 건국대학교 의과대학
Yeonsil Moon, M.D., Ph.D.

약력

  • 1999~2005 건국대학교 의과대학 졸업
  • 2019~현재 건국대학교 신경과 조교수
  • 2019~현재 광진구 치매안심센터장

수상 및 성과

  • 2012년 서울시 치매관리사업 최우수 논문상
  • 2012년 Alzheimer’s Association International Conference Young Investigator Travel Grant
  • 2014년 대한노인신경의학회 학술상
  • 2022년 대한치매학회 우수 포스터상

저서

  • 젠틀 브레인 트레이너: 데일리 핀포인트 8과 함께 하는 30일간의 브레인 활성화
    (저자: 유희진, 문연실, 발행인: 메디안 북, 2020, ISBN: 9791190450065)

대표연구논문

  1. Kim YS, Park JM, Moon YS, Han SH. Assessment of pain in the elderly: A
    literature review. Natl Med J India. 2017 Jul-Aug;30(4):203-207. doi:
    10.4103/0970-258X.218673. PMID: 29162753.
  2. Kim SH, Noh MY, Kim HJ, Oh KW, Park J, Lee S, Moon Y, Kim YE, Bae JS, Jin HK;
    K-ARPI. A Therapeutic Strategy for Alzheimer’s Disease Focused on Immune-
    inflammatory Modulation. Dement Neurocogn Disord. 2019 Jun;18(2):33-46. doi:
    10.12779/dnd.2019.18.2.33. Epub 2019 Jun 24. PMID: 31297134; PMCID: PMC6609533.
  3. Ryu HJ, Moon Y, Kim M, Kim HJ, Galvin JE, Han SH. Validation of the Korean
    Quick Dementia Rating System (K-QDRS). J Alzheimers Dis. 2021;84(4):1645-1656.
    doi: 10.3233/JAD-210584. PMID: 34719493.
  4. Moon Y, Lim C, Kim Y, Moon WJ. Sex-Related Differences in Regional Blood-
    Brain Barrier Integrity in Non-Demented Elderly Subjects. Int J Mol Sci. 2021
    Mar 11;22(6):2860. doi: 10.3390/ijms22062860. PMID: 33799794; PMCID: PMC8001339.
  5. Kim S, Kim JO, Kwon KJ, Han SH, Moon Y. Associations of truncal body
    composition with cognitive status in patients with dementia. Neurol Sci. 2021
    Jan;42(1):209-214. doi: 10.1007/s10072-020-04503-5. Epub 2020 Jul 2. PMID:
    32617740.
  6. Kim YS, Lee J, Moon Y, Kim KJ, Lee K, Choi J, Han SH. Unmet healthcare needs
    of elderly people in Korea. BMC Geriatr. 2018 Apr 20;18(1):98. doi:
    10.1186/s12877-018-0786-3. PMID: 29678164; PMCID: PMC5910628.
  7. Moon Y, Lee H, Namgung OK, Han SH. Which Stratum of Urban Elderly Is Most
    Vulnerable for Dementia? J Korean Med Sci. 2016 Oct;31(10):1635-40. doi:
    10.3346/jkms.2016.31.10.1635. PMID: 27550494; PMCID: PMC4999408.
  8. Lee JY, Oh SW, Chung MS, Park JE, Moon Y, Jeon HJ, Moon WJ. Clinically
    Available Software for Automatic Brain Volumetry: Comparisons of Volume
    Measurements and Validation of Intermethod Reliability. Korean J Radiol. 2021
    Mar;22(3):405-414. doi: 10.3348/kjr.2020.0518. Epub 2020 Nov 3. PMID: 33236539;
    PMCID: PMC7909859.
  9. Moon Y, Moon WJ, Kim JO, Kwon KJ, Han SH. Role of Muscle Profile in
    Alzheimer’s Disease: A 3-Year Longitudinal Study. Eur Neurol.
    2019;81(5-6):209-215. doi: 10.1159/000502176. Epub 2019 Oct 25. PMID: 31655799.
  10. Moon WJ, Lim C, Ha IH, Kim Y, Moon Y, Kim HJ, Han SH. Hippocampal blood-
    brain barrier permeability is related to the APOE4 mutation status of elderly
    individuals without dementia. J Cereb Blood Flow Metab. 2021
    Jun;41(6):1351-1361. doi: 10.1177/0271678X20952012. Epub 2020 Sep 16. PMID:
    32936729; PMCID: PMC8142140.
  11. Ha IH, Lim C, Kim Y, Moon Y, Han SH, Moon WJ. Regional Differences in Blood-
    Brain Barrier Permeability in Cognitively Normal Elderly Subjects: A Dynamic
    Contrast-Enhanced MRI-Based Study. Korean J Radiol. 2021 Jul;22(7):1152-1162.
    doi: 10.3348/kjr.2020.0816. Epub 2021 Mar 9. PMID: 33739632; PMCID: PMC8236362.
  12. Park M, Moon WJ, Moon Y, Choi JW, Han SH, Wang Y. Region-specific
    susceptibility change in cognitively impaired patients with diabetes mellitus.
    PLoS One. 2018 Oct 11;13(10):e0205797. doi: 10.1371/journal.pone.0205797. PMID:
    30308069; PMCID: PMC6181414.
  13. Lee J, Lee JY, Oh SW, Chung MS, Park JE, Moon Y, Jeon HJ, Moon WJ.
    Evaluation of Reproducibility of Brain Volumetry between Commercial Software,
    Inbrain and Established Research Purpose Method, FreeSurfer. J Clin Neurol. 2021
    Apr;17(2):307-316. doi: 10.3988/jcn.2021.17.2.307. PMID: 33835753; PMCID:
    PMC8053534.
  14. Moon Y, Lim JS, Lee CN, Choi H. Vulnerable Strata to Non-Adherence and
    Overuse in Treatment for Patients with Cognitive Impairment. Dement Neurocogn
    Disord. 2020 Dec;19(4):152-160. doi: 10.12779/dnd.2020.19.4.152. PMID: 33377668;
    PMCID: PMC7781736.
  15. Moon Y, Choi YJ, Kim JO, Han SH. Muscle profile and cognition in patients
    with Alzheimer’s disease dementia. Neurol Sci. 2018 Nov;39(11):1861-1866. doi:
    10.1007/s10072-018-3505-0. Epub 2018 Aug 6. PMID: 30084072.
  16. Moon Y, Han SH, Kim YS, Shin J, Uhm KE, Jeon HJ, Choi J, Lee J. Hospital
    adverse outcomes of the elderly in a tertiary referral hospital: A prospective
    cohort study of 9,586 admissions. Arch Gerontol Geriatr. 2021 Jan-Feb;92:104253.
    doi: 10.1016/j.archger.2020.104253. Epub 2020 Sep 24. PMID: 33032184.
  17. Moon Y, Moon WJ, Kim JO, Kwon KJ, Han SH. Muscle Strength Is Independently
    Related to Brain Atrophy in Patients with Alzheimer’s Disease. Dement Geriatr
    Cogn Disord. 2019;47(4-6):306-314. doi: 10.1159/000500718. Epub 2019 Jul 16.
    PMID: 31311027.
  18. Moon Y, Kim H, Ok Kim J, Han SH. Vascular factors are associated with the
    severity of the neuropsychiatric symptoms in Alzheimer’s disease. Int J
    Neurosci. 2014 Jul;124(7):512-7. doi: 10.3109/00207454.2013.856902. Epub 2013
    Nov 13. PMID: 24188046.
  19. Yim Y, Lee JY, Oh SW, Chung MS, Park JE, Moon Y, Jeon HJ, Moon WJ.
    Comparison of Automated Brain Volume Measures by NeuroQuant vs. Freesurfer in
    Patients with Mild Cognitive Impairment: Effect of Slice Thickness. Yonsei Med
    J. 2021 Mar;62(3):255-261. doi: 10.3349/ymj.2021.62.3.255. PMID: 33635016;
    PMCID: PMC7934099.
  20. Moon Y, Moon WJ, Han SH. Pathomechanisms of atrophy in insular cortex in
    Alzheimer’s disease. Am J Alzheimers Dis Other Demen. 2015 Aug;30(5):497-502.
    doi: 10.1177/1533317514566113. Epub 2015 Jan 16. PMID: 25596207.
  21. Kim YS, Han SH, Hwang JH, Park JM, Lee J, Choi J, Moon Y, Kim HJ, Shin GJE,
    Lee JS, Choi YJ, Uhm KE, Kim IA, Nam JW. Development of the Korean framework for
    senior-friendly hospitals: a Delphi study. BMC Health Serv Res. 2017 Aug
    4;17(1):528. doi: 10.1186/s12913-017-2480-0. PMID: 28778159; PMCID: PMC5545032.
  22. Choi JD, Moon Y, Kim HJ, Yim Y, Lee S, Moon WJ. Choroid Plexus Volume and
    Permeability at Brain MRI within the Alzheimer Disease Clinical Spectrum.
    Radiology. 2022 Sep;304(3):635-645. doi: 10.1148/radiol.212400. Epub 2022 May
    17. PMID: 35579521.
  23. Park M, Lee HP, Kim J, Kim DH, Moon Y, Moon WJ. Brain myelin water fraction
    is associated with APOE4 allele status in patients with cognitive impairment. J
    Neuroimaging. 2022 May;32(3):521-529. doi: 10.1111/jon.12960. Epub 2021 Dec 29.
    PMID: 34964524.
  24. Jeong M, Jin J, Kim JH, Moon Y, Choi JW, Kim HY. Incidental Hippocampal
    Hyperintensity on Diffusion-weighted MRI: Individual Susceptibility to Transient
    Global Amnesia. Neurologist. 2017 Jul;22(4):103-106. doi:
    10.1097/NRL.0000000000000123. PMID: 28644249.
  25. Bagaria J, Moon Y, Bagyinszky E, Shim KH, An SSA, Kim S, Han SH. Whole Exome
    Sequencing Reveals a Novel APOE Mutation in a Patient With Sporadic Early-Onset
    Alzheimer’s Disease. Front Neurol. 2022 Jun 10;13:899644. doi:
    10.3389/fneur.2022.899644. PMID: 35756922; PMCID: PMC9226417.
  26. Moon Y, Moon WJ, Kwon H, Lee JM, Han SH. Vitamin D deficiency disrupts
    neuronal integrity in cognitively impaired patients. J Alzheimers Dis.
    2015;45(4):1089-96. doi: 10.3233/JAD-143063. PMID: 25672764.
  27. Cho J, Park M, Moon WJ, Han SH, Moon Y. Sarcopenia in patients with
    dementia: correlation of temporalis muscle thickness with appendicular muscle
    mass. Neurol Sci. 2022 May;43(5):3089-3095. doi: 10.1007/s10072-021-05728-8.
    Epub 2021 Nov 30. PMID: 34846582.
  28. Uhm KE, Oh-Park M, Kim YS, Park JM, Choi J, Moon Y, Han SH, Hwang JH, Lee
    KS, Lee J. Applicability of the 48/6 Model of Care as a Health Screening Tool,
    and its Association with Mobility in Community-Dwelling Older Adults. J Korean
    Med Sci. 2020 Feb 24;35(7):e43. doi: 10.3346/jkms.2020.35.e43. PMID: 32080986;
    PMCID: PMC7036345.
  29. Kim YS, Lee J, Moon Y, Kim HJ, Shin J, Park JM, Uhm KE, Kim KJ, Yoo JA, Oh
    YK, Byeon P, Lee K, Han SH, Choi J. Development of a senior-specific, citizen-
    oriented healthcare service system in South Korea based on the Canadian 48/6
    model of care. BMC Geriatr. 2020 Jan 31;20(1):32. doi:
    10.1186/s12877-019-1397-3. PMID: 32005155; PMCID: PMC6995103.
  30. Al-Amin M, Bradford D, Sullivan RKP, Kurniawan ND, Moon Y, Han SH, Zalesky
    A, Burne THJ. Vitamin D deficiency is associated with reduced hippocampal volume
    and disrupted structural connectivity in patients with mild cognitive
    impairment. Hum Brain Mapp. 2019 Feb 1;40(2):394-406. doi: 10.1002/hbm.24380.
    Epub 2018 Sep 25. PMID: 30251770; PMCID: PMC6865549.
  31. Ryu HJ, Kim M, Moon Y, Choi Y, Han JY, Galvin JE, Han SH. Validation of the
    Korean Version of the Lewy Body Composite Risk Score (K-LBCRS). J Alzheimers
    Dis. 2017;55(4):1395-1401. doi: 10.3233/JAD-160463. PMID: 27834773.
  32. Choi H, Bae JH, Lim JS, Moon Y, Park KH, Kim SH, Lee CN. Survey of Current
    Status and Cognition of Activities of Daily Living in Dementia Patients: the
    2018 “Il-sang-ye-chan” Campaign. Dement Neurocogn Disord. 2019 Mar;18(1):1-9.
    doi: 10.12779/dnd.2019.18.1.1. Epub 2019 Apr 25. PMID: 31097967; PMCID:
    PMC6494780.
  33. Lee JH, Kim YJ, Moon Y, Cho HJ, Kim HY. Acute simultaneous multiple lacunar
    infarcts: a severe disease entity in small artery disease. Eur Neurol.
    2012;67(5):303-11. doi: 10.1159/000336061. Epub 2012 Apr 17. PMID: 22517446.
  34. Park M, Moon Y, Han SH, Moon WJ. Motor cortex hypointensity on
    susceptibility-weighted imaging: a potential imaging marker of iron accumulation
    in patients with cognitive impairment. Neuroradiology. 2019 Jun;61(6):675-683.
    doi: 10.1007/s00234-019-02159-3. Epub 2019 Jan 28. PMID: 30693411.
  35. Park M, Moon Y, Han SH, Kim HK, Moon WJ. Myelin loss in white matter
    hyperintensities and normal-appearing white matter of cognitively impaired
    patients: a quantitative synthetic magnetic resonance imaging study. Eur Radiol.
    2019 Sep;29(9):4914-4921. doi: 10.1007/s00330-018-5836-x. Epub 2018 Nov 28.
    PMID: 30488109.
  36. Yoon KH, Moon YS, Lee Y, Choi SH, Moon SY, Seo SW, Park KW, Ku BD, Han HJ,
    Park KH, Han SH, Kim EJ, Lee JH, Park SA, Shim YS, Kim JH, Hong CH, Na DL, Ye
    BS, Kim HJ, Moon Y, Lee SS, Kim DH; CARE (Caregivers of Alzheimer’s Disease
    Research) Investigators. The moderating effect of religiosity on caregiving
    burden and depressive symptoms in caregivers of patients with dementia. Aging
    Ment Health. 2018 Jan;22(1):141-147. doi: 10.1080/13607863.2016.1232366. Epub
    2016 Sep 23. PMID: 27661263.
  37. Yim Y, Choi JD, Cho JH, Moon Y, Han SH, Moon WJ. Magnetic susceptibility in
    the deep gray matter may be modulated by apolipoprotein E4 and age with regional
    predilections: a quantitative susceptibility mapping study. Neuroradiology. 2022
    Jul;64(7):1331-1342. doi: 10.1007/s00234-021-02859-9. Epub 2022 Jan 4. PMID:
    34981175.
  38. Moon Y, Oh J, Kwon KJ, Han SH. Transient global amnesia: Only in already
    disrupted neuronal integrity of memory network? J Neurol Sci. 2016 Sep
    15;368:187-90. doi: 10.1016/j.jns.2016.05.035. Epub 2016 May 17. PMID: 27538630.
  39. Kim SH, Kang HS, Kim HJ, Moon Y, Ryu HJ, Kim MY, Han SH. The effect of
    ischemic cholinergic damage on cognition in patients with subcortical vascular
    cognitive impairment. J Geriatr Psychiatry Neurol. 2012 Jun;25(2):122-7. doi:
    10.1177/0891988712445089. PMID: 22689705.
  40. Moon Y, Han SH, Moon WJ. Patterns of Brain Iron Accumulation in Vascular
    Dementia and Alzheimer’s Dementia Using Quantitative Susceptibility Mapping
    Imaging. J Alzheimers Dis. 2016;51(3):737-45. doi: 10.3233/JAD-151037. PMID:
    26890777.
돌아가기